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SPX proteins, as phosphorus receptors, can avoid toxicity caused by phosphorus over-accumulation by interacting with PHR1 ( Arabidopsis ) or PHR2 ( Oryza sativa ), and inhibiting their transcriptional activities under normal conditions, while SPX proteins do not affect PHR transcriptional activities when plants are in low phosphorus environments (Wang et al., 2014)

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However, Mashayekhi-Sardoo et al cautioned, based on human and preclinical studies, that TQ be considered as an “almost safe chemical” in light of the need for a more in-depth toxicological profile of TQ before its use as a therapeutic agent in humans